ML345

ML345

Stock Code: 3574496
Manufacturer Part No: SML1117-5MG
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£172.71 (exc VAT) per 5MG
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Biochem/physiol Actions


ML345 is a cell penetrant, potent and moderately selective insulin degrading enzyme (IDE) inhibitor that targets Cys819 in IDE. IDE is involved in β-chain of insulin degradation and linked to β-amyloid degradation. Recent findings indicate that IDE inhibition is a valid strategy for diabetes mellitus type 2 (DMT2) treatment.


ML345 has effective concentration (EC50) value of 188 nM.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyFVKOFZKSMMIUTL-UHFFFAOYSA-N
InChI1S/C21H22FN3O5S2/c22-15-1-4-20-17(13-15)21(26)25(31-20)19-14-16(32(27,28)24-7-11-30-12-8-24)2-3-18(19)23-5-9-29-10-6-23/h1-4,13-14H,5-12H2
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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