METAMIZOLE SODIUM HYDRATE

METAMIZOLE SODIUM HYDRATE

Stock Code: 3574977
Manufacturer Part No: SML1488-50MG
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£314.79 (exc VAT) per 50MG
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Biochem/physiol Actions


Metamizole (Dipyrone) is a potent analgesic and antipyretic. Metamizole inhibits prostaglandin synthesis in both the periphery and the central nervous system. Metamizole may act as a prodrug. It is rapidly hydrolyzed to N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA) which inhibit cyclo-oxygenase activity and can be further acylated with arachidonic acid forming compounds that bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors. It is believed that these metabolites play a major role in metamizole activity. Metamizole has been withdrawn from clinical use in several countries because of a side-effect of agranulocytosis in some patients.


General description


Metamizole sodium is a nonsteroidal anti-inflammatory drug (NSAID). It is widely used as an analgesic and antipyretic agent.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyUNZIDPIPYUMVPA-UHFFFAOYSA-M
InChI1S/C13H17N3O4S.Na.H2O/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;;/h4-8H,9H2,1-3H3,(H,18,19,20);;1H2/q;+1;/p-1
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityH2O: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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