MARINOPYRROLE A

MARINOPYRROLE A

Stock Code: 3575045
Manufacturer Part No: SML1533-5MG
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£196.39 (exc VAT) per 5MG
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Biochem/physiol Actions


Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737.


General description


Marinopyrrole A (Maritoclax) is a member of phenolic 1,3?-bipyrroles family targeting actin group.


Packaging


5, 25 mg in glass bottle

Colourlight yellow to dark yellow
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥95% (HPLC)

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