MADRASIN

MADRASIN

Stock Code: 3574876
Manufacturer Part No: SML1409-5MG
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£146.25 (exc VAT) per 5MG
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Application


Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.


Biochem/physiol Actions


Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.


Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.


Packaging


5, 25 mg in glass bottle

Colour, white to dark brown
Quality Level100
InChI keyQQJIYKXTEMDJFM-UHFFFAOYSA-N
InChI1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 0.5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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