LP-211

LP-211

Stock Code: 3575091
Manufacturer Part No: SML1561-5MG
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£178.29 (exc VAT) per 5MG
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Biochem/physiol Actions


LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

Colourcolorless
Quality Level100
InChI keyBQEDZLDNNBDKDS-UHFFFAOYSA-N
InChI1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formfilm
Assay≥98% (HPLC)

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