L755507

L755507

Stock Code: 3574805
Manufacturer Part No: SML1362-5MG
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£218.68 (exc VAT) per 5MG
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Application


L755507 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.


Biochem/physiol Actions


L755507 is a potent β3-adrenergic receptor partial agonist.


L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.


L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.


General description


L755507 is a derivative of 4-acylaminobenzenesulfonamide.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyNYYJKMXNVNFOFQ-MHZLTWQESA-N
InChI1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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