KU-60019

KU-60019

Stock Code: 3574885
Manufacturer Part No: SML1416-25MG
Order Now for 7 day delivery
£533.46 (exc VAT) per 25MG
Quantity: - +

Application


KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.


Biochem/physiol Actions


KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel.


Other Notes


KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keySCELLOWTHJGVIC-BGYRXZFFSA-N
InChI1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥97% (HPLC)

There are no downloads for this product.