KU-55933

KU-55933

Stock Code: 3574486
Manufacturer Part No: SML1109-25MG
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£442.93 (exc VAT) per 25MG
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Application


KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.


Biochem/physiol Actions


KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyXRKYMMUGXMWDAO-UHFFFAOYSA-N
InChI1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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