KNK437

KNK437

Stock Code: 3574301
Manufacturer Part No: SML0964-25MG
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£416.46 (exc VAT) per 25MG
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Application


KNK437 has been used:as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cellsas an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cellsas a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release


Biochem/physiol Actions


KNK437is a benzylidene lactam compound.


KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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