JNJ-55511118

JNJ-55511118

Stock Code: 3575341
Manufacturer Part No: SML1747-5MG
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£149.04 (exc VAT) per 5MG
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Biochem/physiol Actions


JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors that requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampus, and a strong anti-convulsant effect.


JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitor, mainly in the hippocampus region.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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