ISRIB

ISRIB

Stock Code: 3574161
Manufacturer Part No: SML0843-25MG
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£689.46 (exc VAT) per 25MG
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Application


ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.


Biochem/physiol Actions


ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)? phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction.


ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. ISRIB enhances cognitive memory in rodents.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyHJGMCDHQPXTGAV-IYARVYRRSA-N
InChI1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 1 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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