ILOPERIDONE

ILOPERIDONE

Stock Code: 3575035
Manufacturer Part No: SML1528-50MG
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£500.04 (exc VAT) per 50MG
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Biochem/physiol Actions


Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki ﹤ 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki ﹤ 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki ﹤ 10 nM) which may contribute to the drug’;s efficacy on mood and cognition.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyXMXHEBAFVSFQEX-UHFFFAOYSA-N
InChI1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 5 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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