GV-58

GV-58

Stock Code: 3575072
Manufacturer Part No: SML1551-1MG
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£77.30 (exc VAT) per 1MG
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Biochem/physiol Actions


GV-58 is a roscovitine analog that retains the ability to prolong the open state of calcium channels, but unlike roscovitine, is inactive against Cdk activity. GV-58 is a selective agonist of N-type and P/Q type calcium channels, which are critical to the triggering of neurotransmitter release at the neuromuscular junction. GV-58 has been studied as a possible therapeutic agent in a mouse model of Lambert-Eaton myasthenic syndrome (LEMS). The EC50 values for activation of N-, P/Q- and L- type calcium channels are 6.8, 9.9 and >100 µM, respectively.


Packaging


1, 5 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyDPTXJOUVBMUSGY-CYBMUJFWSA-N
InChI1S/C18H26N6OS/c1-4-8-24-11-20-15-16(19-9-14-7-6-12(3)26-14)22-18(23-17(15)24)21-13(5-2)10-25/h6-7,11,13,25H,4-5,8-10H2,1-3H3,(H2,19,21,22,23)/t13-/m1/s1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥97% (HPLC)

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