GSK461364A

GSK461364A

Stock Code: 3575540
Manufacturer Part No: SML1912-5MG
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£151.82 (exc VAT) per 5MG
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Biochem/physiol Actions


GSK461364 is an imidazotriazine derivate that inhibits polo-like kinase 1 (Plk1) in a potent, reversible, ATP-competitive, and highly selective manner (Kiapp ﹤0.5 nM vs. 0.86 µM for Plk2 and 200 µM for Plk3; ATP Kmapp = 16 µM), exhibiting much reduced or little potency toward a panel of 262 kinases. GSK461364A inhibits the growth of various cancer cultures (IG50 ﹤100 nM) as a result of either growth arrest (cytostasis) or cytotoxicity in vitro and effectively suppresses the expansion of various human tumor exnografts in mice in vivo (25 or 50 mg/kg i.p. q2dx12).

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 25 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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