GOMISIN A

GOMISIN A

Stock Code: 3574658
Manufacturer Part No: SML1251-25MG
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£472.18 (exc VAT) per 25MG
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Biochem/physiol Actions


Gomisin A guards against hepatic and renal injury stimulated by CCl(4) (carbon tetrachloride) exposure by differential modulation of the mitogen-activated protein kinases (MAPK) signal transduction pathway. It also blocks inflammatory responses, promoted by lipopolysaccharide in N9 microglia by blocking the NF-?B (nuclear factor kappa light chain enhancer of activated B cells)/MAPKs pathway.


Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese that exhibit a wide variety of interesting biological activities, including hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory. Gomisin A suppressed the expressions of iNOS and COX-2 in LPS-stimulated N9 microglia through suppression of NF-κB/MAPKs pathway.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyZWRRJEICIPUPHZ-MYODQAERSA-N
InChI1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder

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