GEFITINIB

GEFITINIB

Stock Code: 3575227
Manufacturer Part No: SML1657-10MG
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£140.68 (exc VAT) per 10MG
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Application


Gefitinib has been used : To study its effective use in endometrial cancer therapy Cell proliferation, cell cycle and apoptosis assays Cell viability assay and colony formation assay


Biochem/physiol Actions


Gefitinib is a selective epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Gefitinib has antineoplastic activity, and has been approved for the treatment on non-small cell lung cancer (NSCLC).Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.


Packaging


10, 50 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyXGALLCVXEZPNRQ-UHFFFAOYSA-N
InChI1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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