G3335

G3335

Stock Code: 3574924
Manufacturer Part No: SML1449-250MG
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£472.18 (exc VAT) per 250MG
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Biochem/physiol Actions


G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 µM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 µM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.


Packaging


50, 250 mg in glass bottle

Colourwhite to off-white
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder
Assay≥98% (HPLC)

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