FIN56

FIN56

Stock Code: 3575330
Manufacturer Part No: SML1740-25MG
Order Now for 7 day delivery
£536.25 (exc VAT) per 25MG
Quantity: - +

Biochem/physiol Actions


Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.


FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC50 value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.room temp
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.