FEXINIDAZOLE

FEXINIDAZOLE

Stock Code: 3576438
Manufacturer Part No: SML2524-5MG
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£156.00 (exc VAT) per 5MG
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Biochem/physiol Actions


Anti Trypanosoma, Leishmania agent.


Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites that are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.

Colourlight yellow to dark brown
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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