FEXARAMINE

FEXARAMINE

Stock Code: 3574844
Manufacturer Part No: SML1390-25MG
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£668.57 (exc VAT) per 25MG
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Application


Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-?B ligand)-induced osteoclastogenesis in mouse model.


Biochem/physiol Actions


Fexaramine is a potent and selective agonist of the bile acid sensor farnesoid X receptor (FXR) in the gut with an EC50 of 25 nM and no activity found for other nuclear receptors. Fexaramine induces enteric fibroblast growth factor 15 (FGF15), causing alterations in bile acid composition without activating FXR target genes in the liver. In mouse studies, fexaramine enhanced thermogenesis and browning of white adipose tissue while reducing diet-induced weight gain, body-wide inflammation and hepatic glucose production. Fexaramine also improved insulin responsiveness.


Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.


General description


Fexaramine belongs to the nuclear hormone receptor family.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyVLQTUNDJHLEFEQ-KGENOOAVSA-N
InChI1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 10 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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