FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to FOXM1 protein and specifically downregulates FOXM1-activated genes.
Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.