Facade®EM (3?-hydroxy-7?,12?-di-((O-?-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used:as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel as an additive in fluorescence quenching experiments of pentaene-SM 18 to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies
Biochem/physiol Actions
Facades can be used for the crystallization of membrane proteins since they are considered as optimized membrane mimetics.
General description
Facade-EM is a two-dimensional amphiphile with hydrophobic and hydrophilic faces that has superior ability to stabilize integral membrane proteins. This new class of detergents represents a departure from traditional one-dimensional polar-head/nonpolar-tail molecules.
Legal Information
Facade is a registered trademark of Avanti Polar Lipids, Inc.