EVEROLIMUS

EVEROLIMUS

Stock Code: 3576083
Manufacturer Part No: SML2282-10MG
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£156.00 (exc VAT) per 10MG
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Application


Everolimus has been used as an mechanistic target of rapamycin complex 1 (mTORC1) inhibitor to study its effect on MCF7 and MDA-MB-231 cell lines.


Biochem/physiol Actions


Everolimus, the 40-O-(2-hydroxyethyl) derivative of rapamycin (sirolimus), is a potent and selective inhibitor of mechanistic target of rapamycin (mTOR). Everolimus is selective for the mTORC1 protein complex. Everolimus exhibit potent immunosuppressive and anticancer activities.


Everolimus, a substrate for P-glycoprotein (P-gp) can be used to treat advanced neuroendocrine tumors (NETs).

Colourwhite to beige
InChI keyHKVAMNSJSFKALM-GKUWKFKPSA-N
InChI1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥95% (HPLC)

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