ETAKG

ETAKG

Stock Code: 3575334
Manufacturer Part No: SML1743-25MG
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£536.25 (exc VAT) per 25MG
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Biochem/physiol Actions


ETaKG is a cell-permeable, aqueous stable, bioavailable, non-toxic A-ketoglutarate/2-oxoglutarate (A-KG/2-OG) diester derivative that readily undergoes hydrolysis by cytosolic esterases to A-KG. The monoester analog, TaKG is also membrane permeant. ETaKG elevates intracellular [A-KG] by ~15-fold in a prologned fashion, destabilizes HIF-1A/2A and reactivates prolyl hydroxylases (PHDs) in hypoxic HCT116, A431 and RPE cells at 2 mM. Further, shown to selectively trigger PHD-dependent cell death in hypoxic cells and decreases cellular [ATP] and glucose uptake. ETaKG has shown to reduce glucose metabolism, elevate [A-KG] levels and suppress A375 xenograft tumor growth (750 mg/kg of mice, p.o., q.d., 14 days). Also, induces mTORC1 lysosomal translocation and stimulates mTORC1 activity in the absence of glutaminolysis in U2OS cells.

Colourcolorless to light yellow
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formoil
Assay≥95% (HPLC)

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