ESI-05

ESI-05

Stock Code: 3575531
Manufacturer Part No: SML1907-25MG
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£605.89 (exc VAT) per 25MG
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Application


ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.


Biochem/physiol Actions


ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 µM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyCGPHOZWFSFNOEQ-UHFFFAOYSA-N
InChI1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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