ERLOTINIB HYDROCHLORIDE

ERLOTINIB HYDROCHLORIDE

Stock Code: 3575889
Manufacturer Part No: SML2156-100MG
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Application


Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.


Biochem/physiol Actions


Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.


General description


Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.

Colourwhite to beige
InChI keyGTTBEUCJPZQMDZ-UHFFFAOYSA-N
InChI1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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