ENDOSIDIN2

ENDOSIDIN2

Stock Code: 3575259
Manufacturer Part No: SML1681-5MG
Order Now for 7 day delivery
£140.68 (exc VAT) per 5MG
Quantity: - +

Biochem/physiol Actions


Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd= 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyUIADDCURKKFTFW-QGMBQPNBSA-N
InChI1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.