Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds to the viral 2′O methyltransferase of nonstructural protein 5 (NS5). It also decreases the DENV2-induced STAT1 phosphorylation and IFN-stimulated genes (ISGs) expression.
The antiviral effect of Diasarone-I includes half maximal effective concentration (EC50) of 4.5 ?M and half maximal cytotoxicity concentration (CC50) of >80 ?M.