DBeQ, >=98% (HPLC)

DBeQ, >=98% (HPLC)

Stock Code: 3573987
Manufacturer Part No: SML0031-25MG
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£520.93 (exc VAT) per 25MG
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Application


HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.


Biochem/physiol Actions


DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyQAIMUUJJAJBPCL-UHFFFAOYSA-N
InChI1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥20 mg/mL
Formpowder
Assay≥98% (HPLC)

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