Cyclosporin A, >=98.5%

Cyclosporin A, >=98.5%

Stock Code: 3577571
Manufacturer Part No: 30024-25MG
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£135.00 (exc VAT) per 25MG
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Application


Cyclosporin A is used for immunosuppressive studies .


Biochem/physiol Actions


A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.


General description


Chemical structure: peptide


Other Notes


Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.


Packaging


25, 100 mg in glass bottle


Bottomless glass bottle. Contents are inside inserted fused cone.

Colourwhite to off-white
InChI keyPMATZTZNYRCHOR-CGLBZJNRSA-N
InChI1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(
ManufacturerSIGMA-ALDRICH
Formpowder
Assay97.0-101.5% (on dried basis)

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