CP724714

CP724714

Stock Code: 3573773
Manufacturer Part No: PZ0335-5MG
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£140.68 (exc VAT) per 5MG
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Biochem/physiol Actions


CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.


Legal Information


Pfizer is a registered trademark of Pfizer, Inc.


Sold for research purposes under agreement from Pfizer Inc.


Other Notes


CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.


This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
InChI keyLLVZBTWPGQVVLW-SNAWJCMRSA-N
InChI1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (HPLC)

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