Colchicine, BioReagent, plant cell culture tested, >=95% (HPLC)

Colchicine, BioReagent, plant cell culture tested, >=95% (HPLC)

Stock Code: 3581844
Manufacturer Part No: C3915-500MG
Order Now for 21 day delivery
£166.93 (exc VAT) per 500MG
Quantity: - +

Application


Colchicine has been used:as an inhibitor of tubulin polymerization in bone-marrow-derived macrophagesfor the inhibition of in vitro neurite outgrowth in human neuronal cellsas microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)


Biochem/physiol Actions


Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.


Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis.


General description


Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C.


Packaging


500 mg in glass bottle


1, 5 g in glass bottle


Preparation Note


Preparation and Use

mp150-160 °C (dec.) (lit.)
InChI keyIAKHMKGGTNLKSZ-INIZCTEOSA-N
InChI1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
ManufacturerSIGMA-ALDRICH
Product LineBioReagent
Formpowder
Assay≥95% (HPLC)

There are no downloads for this product.