CLP257

CLP257

Stock Code: 3574813
Manufacturer Part No: SML1368-5MG
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£167.14 (exc VAT) per 5MG
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Application


CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.


Biochem/physiol Actions


In streptozotocin treated rats, by activating a K+- Cl- cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates ?-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.


CLP257 is a selective K+-Cl− cotransporter KCC2 activator that restored impaired Cl− transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.


Packaging


5, 25 mg in glass bottle

Colour, white to yellow to light brown
Quality Level100
InChI keySKCADXVKQRCWTR-GHXNOFRVSA-N
InChI1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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