CID755673, >=98% (HPLC), powder

CID755673, >=98% (HPLC), powder

Stock Code: 3573966
Manufacturer Part No: SML0003-25MG
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£557.14 (exc VAT) per 25MG
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Application


CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells.


Biochem/physiol Actions


CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCµ), PKD2, and PKD3 (PKCΝ). CID755673 is not competitive with ATP.


CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution.


Features and Benefits


This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


Packaging


5, 25 mg in glass bottle

Colourwhite to tan
Quality Level100
InChI keyAACFPJSJOWQNBN-UHFFFAOYSA-N
InChI1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: ≥15 mg/mL
Formpowder
Assay≥98% (HPLC)

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