CHLORFLAVONIN

CHLORFLAVONIN

Stock Code: 3576109
Manufacturer Part No: SML2297-25MG
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£449.89 (exc VAT) per 25MG
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Biochem/physiol Actions


Originally isolated from Aspergillus candidus Link, Chlorflavonin is a non-cytotoxic (up to 100 µM; MRC-5 and THP-1) antibiotic with antifungal activity against certain species of mold fungi (MIC = 0.08 µg/mL against A. amstelodami, A. fumigalus, A. ochraceous; Paecilomyces variotii MIC = 2.5 µg/mL, Botrytis cinerea MIC = 5 µg/mL). Chlorflavonin also exhibits antibiotic activity against M. tuberculosis (MIC90 = 1.56 µM) by targeting acetohydroxyacid synthase (AHAS) catalytic subunit ilvB1. Chlorflavonin is superior to streptomycin against M. tuberculosis inside infected macrophages, synergizes with isoniazid and delamanid, leading to a complete sterilization in liquid cultures.

Colourwhite to beige
InChI keyJLSQXYITDXJTKL-UHFFFAOYSA-N
InChI1S/C18H15ClO7/c1-23-11-7-10(20)12-14(22)18(25-3)15(26-17(12)16(11)24-2)8-5-4-6-9(19)13(8)21/h4-7,20-21H,1-3H3
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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