CHIR 98014

CHIR 98014

Stock Code: 3574461
Manufacturer Part No: SML1094-25MG
Order Now for 7 day delivery
£945.75 (exc VAT) per 25MG
Quantity: - +

Application


CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons. It has also been used as a Wnt/?-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons.


Biochem/physiol Actions


CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2.


Packaging


5, 25 mg in glass bottle

Colourwhite to brown
Quality Level100
InChI keyMDZCSIDIPDZWKL-UHFFFAOYSA-N
InChI1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 0.5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.