Cecropin A, >=97% (HPLC), powder

Cecropin A, >=97% (HPLC), powder

Stock Code: 3589954
Manufacturer Part No: C6830-.1MG
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Amino Acid Sequence

Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2

Application

Cecropin A has been used as an antimicrobial peptide (AMP): to test its cytotoxic effect on breast adenocarcinoma (MDA-MB-231) and human mesothelioma (M14K) cell linesin ultrasensitive radial diffusion assay against E coli to test Galleria mellonella protein 24 and apolipophorin III effectsto test its minimal inhibitory concentrations (MICs) in sensitivity assay for Photorhabdus variants

Biochem/physiol Actions

Cecropin A interacts with cell membranes and makes it permeable for electrolytes. Cecropin A thus, favors cytolysis and finally cell death in the hepatocellular carcinoma and lymphoma. The synthetic cecropin A in transgenic rice confers protection against bacterial as well as fungal pathogens.

Antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.

General description

Cecropin A belongs to cecropin class and comprises 37 amino acid residues in L configuration. Structurally, this peptide has a C-terminal hydrophobic ?-helical structure and the amphipathic N-terminal end. Cecropin A is linear and cationic in nature.

Other Notes

Lyophilized from 0.1% TFA in H2O

Quality Level200
InChI keyHCQPHKMLKXOJSR-IRCPFGJUSA-N
InChI1S/C184H313N53O46/c1-27-98(16)145(182(282)235-149(102(20)31-5)181(281)218-115(59-39-46-76-187)159(259)206-103(21)152(252)205-92-138(246)237-82-52-65-130(237)17
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
Formpowder
Assay≥97% (HPLC)

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