CDN1163

CDN1163

Stock Code: 3575261
Manufacturer Part No: SML1682-5MG
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Biochem/physiol Actions


CDN1163 treatment declined the hepatic expression of genes implicated in gluconeogenesis and lipogenesis as well as attenuated endoplasmic reticulum (ER) stress response and ER stress-induced apoptosis. CDN1163 interacts with sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and enhances ER Ca2+ content.


CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyGVGVYDCVFBGALZ-UHFFFAOYSA-N
InChI1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
SolubilityDMSO: 5 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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