CCG-100602

CCG-100602

Stock Code: 3576102
Manufacturer Part No: SML2292-5MG
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£77.16 (exc VAT) per 5MG
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Biochem/physiol Actions


CCG-100602 aids in preventing fibrosis around the temporomandibular joint (TMJ).


CCG-100602 is a CCG-1423 analog with significantly less cytotoxicity (0/14% WST-1 inhibition by 10/100 µM CCG-100602 vs. 44% by 10 µM CCG-1423) and similar efficacy against Rho/MKL1/SRF pathway-mediated transcription (by 78% with 100 µM CCG-100602 vs. 74% with 10 µM CCG-1423; IC50 = 9.8 µM/CCG-100602 vs. 1.5 µM/CCG-1423; by PC-3 SRE-luciferase assay), albeit at a reduced potency. CCG-100602 reduces the stiffening of spontaneously hypertensive rats (SHR) derived aortic VSMCs (1.12 µM) by inhibiting SRF/myocardin interaction and abrogates the increased aortic wall stiffness in SHR rats in vivo (7.5 mg/kg/d via s.c. osmotic pumps for 2 wks).

Colourwhite to beige
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityDMSO: 2 mg/mL, clear
Formpowder
Assay≥98% (HPLC)

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