CBR-5884

CBR-5884

Stock Code: 3575226
Manufacturer Part No: SML1656-5MG
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£140.68 (exc VAT) per 5MG
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Application


CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.


Biochem/physiol Actions


CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.


Packaging


5, 25 mg in glass bottle

Colourwhite to beige
Quality Level100
InChI keyQBVIRPJBDIZKBC-UHFFFAOYSA-N
InChI1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: 20 mg/mL, clear
Formpaste
Assay≥98% (HPLC)

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