C646, >=98% (HPLC)

C646, >=98% (HPLC)

Stock Code: 3573965
Manufacturer Part No: SML0002-5MG
Order Now for 5 day delivery
£204.75 (exc VAT) per 5MG
Quantity: - +

Application


C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.


Biochem/physiol Actions


C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.


C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-?B, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.


Features and Benefits


This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Packaging


5, 25 mg in glass bottle

Colourred to brown
Quality Level100
InChI keyHEKJYZZSCQBJGB-UNOMPAQXSA-N
InChI1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
ManufacturerSIGMA-ALDRICH
SolubilityDMSO: >25 mg/mL
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.