Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology

Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology

Stock Code: 3581824
Manufacturer Part No: B6542-25MG
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£930.43 (exc VAT) per 25MG
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Application


Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport


Biochem/physiol Actions


Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.


General description


Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.


Chemical structure: macrolide


Packaging


5, 25 mg in glass bottle


Principle


Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.

InChI keyKQNZDYYTLMIZCT-KQPMLPITSA-N
InChI1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥99% (HPLC and TLC)

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