BPV(PIC)

BPV(PIC)

Stock Code: 3574203
Manufacturer Part No: SML0885-5MG
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£136.78 (exc VAT) per 5MG
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Application


bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.


Biochem/physiol Actions


bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.


bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 µM for PTPβ and 61 µM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).


Other Notes


Light Sensitive


Packaging


5, 25 mg in glass bottle

Colourfaintly yellow to dark yellow
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityH2O: 20 mg/mL, clear
Formpowder
Assay≥95% V basis

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