BPV(HOPIC)

BPV(HOPIC)

Stock Code: 3574200
Manufacturer Part No: SML0884-25MG
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£409.50 (exc VAT) per 25MG
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Application


bpV(HOpic) has been used in pharmacological perturbation of cell migration related signaling pathway.


Biochem/physiol Actions


bpV(OHpic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(HOpic) are 14 nM for PTEN compared to 4.9 µM for PTPβ and 25.3 µM for PTP-1β. bpV(HOpic) has been shown to enhance PI3K/Akt signaling that could prevent myocardium from ischemia-reperfusion injury.


Other Notes


Soluble in DMSO or water. NOTE: The product is not stable in water. Decomposition starts immediately after solubilization. Rate of decomposition is slower in dry DMSO.


Packaging


5, 25 mg in glass bottle

Colourfaintly yellow to dark yellow
Quality Level100
ManufacturerSIGMA-ALDRICH
Storage Temp.−20°C
SolubilityH2O: 20 mg/mL, clear
Formpowder
Assay≥90% V basis

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