1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, powder

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, powder

Stock Code: 3591909
Manufacturer Part No: O3636-5MG
Order Now for 21 day delivery
£158.79 (exc VAT) per 5MG
Quantity: - +

Application

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for affinity selection-mass spectrometry (AS-MS) compound binding assay, as a soluble guanylate cyclase (sGC) inhibitor to inhibit S-nitroso-N-acetyl-DL-penicillamine (SNAP)-induced cGMP production.

Biochem/physiol Actions

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

Caution

Hygroscopic

Packaging

5, 25 mg in glass bottle

Colourpale yellow
Quality Level200
InChI keyLZMHWZHOZLVYDL-UHFFFAOYSA-N
InChI1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥98% (TLC)

There are no downloads for this product.