alpha1-Antichymotrypsin from human plasma, >=92.5% (SDS-PAGE), lyophilized powder

alpha1-Antichymotrypsin from human plasma, >=92.5% (SDS-PAGE), lyophilized powder

Stock Code: 3586229
Manufacturer Part No: A9285-.1MG
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Application


?1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays.


Biochem/physiol Actions


?1-Antichymotrypsin (?1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC).


Specific inhibitor of chymotrypsin-like serine proteases. Promotes amyloid-β polymerization in vitro and in vivo. Levels in plasma and cerebrospinal fluid have been found to correlate with progression of dementia in Alzheimer′s patients and induce phosphorylation of tau protein in neurons.


General description


?1-Antichymotrypsin (?1-ACT) is also known as serpin peptidase inhibitor, clade A member 3 (SERPINA3). It is a 68 kDa serine protease inhibitor, secreted by the liver. It belongs to the serpin superfamily of protease inhibitors. SERPINA3 is located on human chromosome 14q32.1.


Packaging


Package size based on protein content.


Physical form


Lyophilized powder containing Tris buffer salt and NaCl.

Quality Level200
ManufacturerSIGMA-ALDRICH
Technique(s)microbiological culture: suitable
Storage Temp.−20°C
Formlyophilized powder
Assay≥92.5% (SDS-PAGE)

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