4-Bromo-calcium Ionophore A23187, powder

4-Bromo-calcium Ionophore A23187, powder

Stock Code: 3577663
Manufacturer Part No: B7272-1MG
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£346.82 (exc VAT) per 1MG
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Application


Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.


4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.


Biochem/physiol Actions


4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.


Other Notes


Analog of calcium ionophore A23187


Packaging


1 mg in glass bottle

Colouryellow
Quality Level200
InChI keyLDXQFZZGVTWFCF-FHYGWRBKSA-N
InChI1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Solubilityethanol: 20 mg/mL, DMSO: soluble
Formpowder

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