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Stock Code: 3576980
Manufacturer Part No: T7947-100MG
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Application


(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer?s disease in miceto study its effects on set shifting in ratsto study its effects on rat brain as a result of its long-term use


Biochem/physiol Actions


(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).


Norepinephrine uptake blocker.


Features and Benefits


This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.


Packaging


25, 50, 100 mg in glass bottle

Quality Level100
InChI keyLUCXVPAZUDVVBT-UNTBIKODSA-N
InChI1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
ManufacturerSIGMA-ALDRICH
Storage Temp.2-8°C
Formsolid

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