23-CGAMP SODIUM SALT

23-CGAMP SODIUM SALT

Stock Code: 3574627
Manufacturer Part No: SML1229-.5UMO
Order Now for 7 day delivery
£373.29 (exc VAT) per EACH
Quantity: - +

Application


2?,3?-cGAMP sodium salt has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.


Biochem/physiol Actions


2′,3′-cGAMP (cyclic [G(2’;,5’;)pA(3’;,5’;)p]) is the natural agonist for the STING (STimulator of INterferon Genes) pathway, discovered to be a pathway for antiviral innate immunity. 2’;3’;-cGAMP is a second messenger produced in mammalian cells by the cytosolic DNA sensor cGAS (cGAMP synthase) to activate innate immune responses by binding to STING and initiating an interferon response. The affinity of 2′3′-cGAMP for human STING is much higher than that of the bacterial 3′3′-cyclic dinucleotides (CDNs), with a Kd of 4.59 nM compared to >1 µM for bacterial 3′3′-CDNs.


Preparation Note


2′,3′-cGAMP is soluble in water and aqueous buffers (>> 5 mM, limits have not been determined).

Colourwhite to beige
Quality Level100
InChI keyXRILCFTWUCUKJR-INFSMZHSSA-N
InChI1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(
ManufacturerSIGMA-ALDRICH
Further Infocontains 0.5µmol of powder (approx. 0.335mg)
Formpowder
Assay≥98% (HPLC)

There are no downloads for this product.