(S)-(+)-Camptothecin, >=90% (HPLC), powder

(S)-(+)-Camptothecin, >=90% (HPLC), powder

Stock Code: 3573326
Manufacturer Part No: C9911-1G
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£931.82 (exc VAT) per 1G
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Biochem/physiol Actions


(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.


Features and Benefits


This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Other Notes


20S isomer


Packaging


1 g in glass bottle


100, 250 mg in glass bottle

mp260 °C (dec.) (lit.)
InChI keyVSJKWCGYPAHWDS-FQEVSTJZSA-N
InChI1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
ManufacturerSIGMA-ALDRICH
Formpowder
Assay≥90% (HPLC)

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